Physiology and pathophysiology of ClC-K/barttin channels

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Physiology and Pathophysiology of ClC-K/barttin Channels

ClC-K channels form a subgroup of anion channels within the ClC family of anion transport proteins. They are expressed predominantly in the kidney and in the inner ear, and are necessary for NaCl resorption in the loop of Henle and for K+ secretion by the stria vascularis. Subcellular distribution as well as the function of these channels are tightly regulated by an accessory subunit, barttin. ...

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ژورنال

عنوان ژورنال: Frontiers in Physiology

سال: 2010

ISSN: 1664-042X

DOI: 10.3389/fphys.2010.00155